Post-amputation phantom limb pain (PLP) is a complex neuropathic pain condition affecting up to 80% of amputees, characterized by burning, electric, or shooting sensations perceived in the missing limb. Current pharmacological treatments offer limited efficacy with significant adverse effects. This case report documents a 64-year-old male amputee with 42-year history of post-traumatic PLP who achieved substantial and sustained pain relief using a liposomal β-caryophyllene (BCP) product as an adjunct to his usual high tetrahydrocannabinol (THC) cannabis which was no longer providing pain relief. BCP is a natural sesquiterpene found in several different plants including clove and cannabis and is a selective cannabinoid receptor 2 agonist. The patient demonstrated progressive improvement over two years, with pain severity reduced substantially enabling return to normal functional and social activities. The therapeutic effects of BCP on neuropathic pain and PLP involves actions at the dorsal root ganglion and reduction of inflammation. BCP may synergize with major cannabinoids found in cannabis, including THC and cannabidiol (CBD). This case study suggests that BCP has potential as a novel therapeutic approach for refractory post-amputation pain syndromes, in conjunction with medicinal cannabis. Further research into BCP with and without cannabis in PLP is warranted.
Citation: Blair, P. & O’Brien, K. (2026). Case Study : Oral Liposomal Beta-Caryophyllene as Adjunct Treatment for Treatment-Refractory Phantom Limb Pain. J Medical Case Repo 8(1):1-8.
DOI : https://doi.org/10.47485/2767-5416.1143