Humans have a keen interest in understanding pain, yet scientific research has not fully explained it due to pain’s connection to suffering, which holds a deeper significance. Pain serves as a sensory and emotional warning system that alerts individuals to tissue damage or degenerative processes occurring on physical, emotional, and spiritual levels. Neurophysiological studies have advanced through various theories, such as intensity and the complexity of connections, leading to the discovery of the spinothalamic pathway and the gate control hypothesis. Concepts like neuroplasticity and the neuromatrix have expanded understanding of pain beyond just specific anatomical structures, highlighting a complex neural network involved in pain perception.
The neuromatrix hypothesis describes pain as arising from a network involving sensory-discriminative, neurohormonal, immune, motivational-affective, and cognitive-evaluative components. Pain signatures are seen as part of the whole self, with the brain responding to stimuli based on their relevance, influenced by stress. Recent attention has been directed towards chronic pathologies that can greatly impact quality of life, often presenting with nonspecific pain linked to the neuromyofascial system. These conditions can be classified as “Chronic Benign Pain Syndromes” (CBCS) and “Myofascial Pain Syndromes” (MPS).
Chronic pain syndromes can include sensory issues and affective problems such as mood swings and anxiety, leading to a decrease in quality of life and often manifesting as nonspecific pain. Pain can be classified into three types: nociceptive pain from tissue damage, neuropathic pain from nervous system complications, and nociplastic pain which occurs from altered central nervous system signal processing without clear peripheral damage, exemplified by fibromyalgia. Nociplastic pain is often chronic and can be related to postural issues and nervous system sensitization, though reliable diagnostic tests for it are lacking. Managing nociplastic pain necessitates a combination of physical approaches, like postural re-education and physiotherapy, along with cognitive interventions to alter pain perception.
This case report discusses a 55-year-old patient with postural syndrome and several health issues, displaying multiple painful symptoms. Initial therapy involved a neuromuscular bite device and physiotherapy. Further treatment focused on bioregulation medicine, utilizing low-dose medications to manage chronic inflammation.
Subsequent treatments focused on mitochondrial support supplements aimed to improve energy production to address her chronic fatigue and enhance cellular function. The patient experienced further symptom improvements and regained ability to perform daily tasks. Six months later, the therapeutic effects persisted.
This case report underscores the links between posture and low-grade inflammation and emphasizes the need for a comprehensive approach in addressing complex pain syndromes. The therapy proposed aims to respond to prevalent musculoskeletal disorders and those related to chronic inflammation, suggesting that bioregulation medicine may further aid in long-term management of chronic conditions alongside established therapies. Recognizing specific postural signs and chronic inflammation requires careful consideration and showcases the challenges faced by medical professionals in providing effective patient care.
Keywords: Pain, CBCS, MPS, Chronic pain syndromes, Nociplastic pain, Neuromatrix, Bioregulation medicine, BrSM
Citation: Caricato, F., & Donati, P. (2026). Nociplastic Pain in Postural Dysfunctions A New Integrated Therapeutic Approach and Exploration of Treatment with Low-Dose Therapies: A Case Report. J Medical Case Repo 8(5):1-9.