Nutthanit Teantunyakij

Objective: To study, and evaluate evidence information based on Aorta Disease Marfan Syndrome and also its treatment from published studies to develop a single synthesis of the results portraying the overall treatment effect.
Methods: We searched online databases for studies and used meta-analytic methods to analyze the data.

Results: Marfan syndrome is a pleiotropic connective tissue disease inherited as an autosomal dominant trait, due to mutations in the FBN1 gene encoding fibrillin 1. It is an important protein of the extracellular matrix that contributes to the final structure of a microfibril. Few cases displaying an autosomal recessive transmission are reported in the world. This disease is considered as a very dangerous one.
However, doctors and scientists are trying to look for a more efficient and best method to treat the disease fully.
Conclusion: Marfan syndrome is an inherited connective-tissue disorder that affects many organ systems, including the skeleton, lungs, eyes, heart and blood vessels. For people with Marfan syndrome, certain activities are thought to increase the risk of serious complications. In general, most people living with Marfan syndrome should exercise regularly through low-intensity, low-impact activities adapted to meet their specific needs. Many people with Marfan syndrome take a beta-blocker medication to reduce stress on the aorta. Some patients with Marfan syndrome take other blood-pressure medications, such as an angiotensin receptor blocker (ARB) or an angiotensin-converting enzyme (ACE) inhibitor. Hospital doctors, family physicians, physiotherapists, physical education teachers, sports coaches and those working in the fitness industry should be aware of the nature of Marfan syndrome and how it relates to exercise ability.

View PDF