Anubha Bajaj

Transitional cell carcinoma emerges from malignant transmutation of transitional epithelium layering intrinsic surface of urinary bladder, ureter, urethra and urachus. Classically, carcinoma of urinary bladder exhibits painless, episodic, intermittent, gross or microscopic haematuria. Transitional cell carcinoma predominantly expounds papillary lesions (70%) whereas nearly 30% neoplasms are non papillary. Transitional cell carcinoma enunciates somatic mutations with genomic deletions in chromosome 9q,9p,11p,17p,13q,14q along with overexpression of RAS oncogene and epidermal growth factor receptor (EGFR). Localized transitional cell carcinoma is aptly subjected to surgical resection.

Keywords : Urothelial carcinoma, papillary variant, carcinoma bladder.

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