Solvent free ball-milling procedure using Sonogashira cross-coupling reaction has been employed successfully for the synthesis of some new N-Biphenyl acetylene substituted heterocyclic molecules. The starting materials, N-4-Bromo-phenyl-4-(Trimethylsilyl)-C-phenyl isoxazoline derivatives have been synthesized from N-4-Bromo-phenyl-4-(Trimethylsilyl)-C-phenyl nitrones and employed in this syntheses. This approach not only make our research work cost-efficient but also follows one of the primary protocols of green chemistry principals (atom efficient reaction). The use of sodium bicarbonate as solid support in the ball-milling procedure enhances the reaction rates as well as yields of the new heterocyclic molecules to a great extent. We have also conducted preliminary screening of these cross-coupling molecules for cancer cell studies and found significant outcomes.
Keywords: Sonogashira cross-coupling reaction, Trimethyl silyl isoxazoline derivative, atom efficient reaction, anticancer study
Citation: Chakraborty, B. et al. (2026). Solid Phase Ball-Milling Procedure for the Synthesis of Some New N-Biphenyl-Acetylene Substituted Heterocycles and Their Potential Anticancer Activities. J mate poly sci, 6(1) :1-7. DOI : https://doi.org/10.47485/2832-9384.1081